Progesterone to help tubular breasts?

    • 3 posts
    December 9, 2009 7:32 PM GMT
    Hi all, sorry this message is so long, I couldn’t seem to make it shorter without being vague. I am a (natal) female with the condition ‘tubular breast hypoplasia’. I think there are some parallels with transwomen’s situations, so I would really appreciate your thoughts.

    I read about how progesterone creates the proper maturation of breasts. My condition is not well understood yet, but some think it’s due to lack of progesterone at puberty. I went to see a specialist in London, who is advising my GP. At my request she has prescribed Utrogestan (a micronised progesterone, 200mg for 12 days each month), but reluctantly - she said ‘progesterone has no effect on breast growth and it wouldn’t do anything for me anyway after puberty’, and she also said bio identical is no different from Provera or the pill (contrary to to what I have read). She said that if after 3 months there are no visible effects she thinks I should discontinue due to the controversy about possible cancer risks.

    I have just started the 3rd cycle of Utrogestan and I have an appt soon to see my GP to discuss what to do next. The first cycle I didn’t see or feel anything. The second cycle I definitely felt my breasts hurt, but so far cannot detect obvious changes to their appearance. I haven’t had any side effects at all, thankfully. I want to continue the treatment but I feel at a loss how to convince my doctors. I have heard that some transwomen have had tubular development when only taking estrogen and some have taken progesterone to correct/prevent this. Does anyone here have experience of taking a progesterone to help change a tubular shape, or do they know of anyone I could talk to? Did it work for you and if so, how long did it take to start seeing effects and how long before you felt the treatment was complete? I know that it usually takes years for transwomen to develop breasts but I hope that with the years of estrogen development that took place in my teens it would not take as long for me to complete development. My breasts look very similar to how my mother remembers hers looking when she was about 13.

    Also I wonder whether taking an estrogen at the same time might help - whether the development requires a synergistic effect somehow, or whether the development I already have, that is basically I think all from my body’s own estrogen, is enough. As I naturally have estrogen in my system I don’t want to have any adverse effects of adding it though. The specialist (verbally) said that I could try taking the pill and see what that did, or the pill and Utrogestan together. She wouldn’t want to prescribe an estrogen and progesterone at the same time because it is not licensed for my condition. But then, nothing is. She suggested the pill ‘Microgynon’. I have researched it on the net and it seems to be commonly prescribed because it is one of the cheapest, but a lot of women seem to get bad side-effects from it esp. mood disorders. I know there is a new (partially) bio-identical pill on the market called Qlaira which is basically 2-3mg of estradiol valerate plus the progestin dienogest. I thought this might be better but am worried that the progestin could have negative side effects and even prevent the progesterone from working, as I have heard on the net: http://www.endo101.com/progest.htm (unfortunately my sources for this are the ‘natural progesterone cream’ people who I think are not necessarily reliable - or at least would not be considered so by my consultant.

    I don’t want to be risky with cancer but I think that the risk is mostly for post menopausal women - I don’t see why it would be riskier for me than taking the pill.
    • 1912 posts
    June 10, 2010 10:37 PM BST
    You can buy that stuff from Inhouse Pharmacy which advertises here at GS. The price has gone down since I tried it years ago. However I read something interesting and that was the progesterone cream available here in the U.S. without a prescription for around $12 is equally effective as pharmaceutical pills sold at a much higher price. I don't know if you have such a product available in the UK but I would think so. I used it on and off for a couple years early on in my transition. I have well shaped B cup breasts so maybe it helped or maybe not. I would not spend a fortune on it unless you really think it is helping. Progesterone's real effect is on a genetic female's uterus. You need to realize that a woman's body chemistry changes during pregnancy and for us to mimic the change won't necessarily be helpful. Lucy had brought up progesterone possibly aided in prevention of tubular breasts and that is pretty much the same information I had heard. Just be cautious of any unintended side effects.
    Hugs,
    Marsha
  • June 10, 2010 11:51 PM BST
    I hope I'm not causing any offence but when I saw the words "Tubular breasts" I instantly thought of Mike Oldfield.
    • Moderator
    • 1652 posts
    December 21, 2009 12:48 PM GMT
    Hi Sara,
    Whether or not progesterone helps breast growth is a bit of an ongoing debate in the TS world. Certainly anything I say here should not be construed as advice on what you ought to do.
    I actually take Utrogestan 100mg. Originally I took it for 10 days per month, then changed to every other day. In the last few months I’ve just been taking it every few days, and during and after a recent holiday have gone without entirely for 4 weeks. It may be my imagination but my breasts feel ever so slightly smaller than they did a few months ago. Obviously I don’t take progesterone to “fix” tubular breasts, but rather to prevent it. There is “strong evidence” to suggest that progesterone aids development of a fuller breast. Psychiatrists at Charing Cross have told me it doesn’t affect breast growth at all, I think that is a ridiculous suggestion. Look at what happens when women get pregnant and their progesterone levels go through the roof; usually bigger, fuller breasts (though obviously there are other factors that may play a part).
    Your GP said that bio identical is no different from Provera or the pill. Nonsense. The side effects are drastically different, and the risks she speaks about are also drastically different. I’d like to see where she’s heard that bio-identical progesterone has any proven risks, because I certainly can’t find any evidence of that. Provera is notorious for its unwanted side effects (such as depression) and its risks. No studies have shown that bio-identicals have any such risks or side effects, none that I’ve found anyway. Provera and Utrogestan are certainly NOT the same. You were right to insist on the latter.
    If I were you I’d give it somewhat longer than 3 months to decide if it’s going to be effective. I’ve been on oestrogen and progesterone for 5 years and have reached an A-cup. I reckon I have another 5 years to go before it becomes unlikely that I will grow any more. My breasts although small have a good shape, certainly not tubular. Clearly my situation is different to yours, but I just wanted to make the point that these things take time, and everyone varies in the time it takes for their development.
    Your specialist voices concern about risks and then suggests prescribing the pill, containing ethinylestradiol - one the most risky forms of oestradiol, but of course prescribed to millions of women world-wide. If she is happy to try adding more oestrogen along with the progesterone there is no reason why the oestrogen should not be bio-identical (though ethinylestradiol is more potent). For your condition I would have thought the progesterone is more important, but oestrogen may help if your levels are naturally low. Or maybe not, I dunno, I’m no expert. I’ve decided on my hormone regime partly through experimentation. You may need to do the same, but give it time, lots of time.
    Well done for persuading the “expert” to give you the safest drug that is mot likely to help you, I know how difficult that can be! If you’re getting soreness/tenderness in the breasts it is probably a good sign that they are changing. I still get that too, but not all the time (“growth spurts”).
    Very best of luck to you Sara, please let us know how it goes. And please feel free to ask again if there’s anything I have missed.
    Lucy
    xx
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