March 17, 2007 8:55 AM GMT
January 24, 2007 11:28 PM GMT
There is no benefit to mixing different types of estradiol, e.g. Valerate and ethinylestradiol, in fact it’s probably not a good idea if only because it would be harder to judge one’s total dosage.
There is no particular reason however not to mix forms of administration of the same type of estradiol, which is in fact what you are suggesting with Climara and Estrace; they are both 17-Beta estradiol (identical to human estradiol). Patches have the advantage over tablets of being less strain on the liver and more efficient, as the liver processes ingested estradiol and excretes most of it from the body (as little as 20% or less of the dose taken will actually get into the bloodstream). Patches have the disadvantage of being more expensive, and to get a high dosage you’d need to wear several at once, and you’d soon run out of skin on which to place them, as you need to vary the point of application.
If one is looking for a higher dose than can be practically achieved from using patches, then taking tablets as well would be a possible way to do this. I actually use estradiol gel twice a day, plus estradiol tablets twice a day. It works for me.
xx