August 22, 2008 6:08 AM BST
My initial response is that it has not been sufficiently studied and that their MIGHT be increased dangers such as bowel cancer associated with this method of taking estrogen. It's also not clear what effect this could have on the intestinal mucosa. Nasal sprays can effect the nasal passages. Taking ethanol, for example, by inhalation or rectally could result in a much larger dose reaching the blood supply much faster with unexpected results/dosages. I suspect an ounce of ethanol inhaled would result in instant illegal or fatal levels of blood alcohol.
Apparently, SOME FORMS of Progesterone have been given rectally. You might want to check this article which I cannot open until i reinstall windows.
http://camelot.lfhk.cuni.[...]ion.doc
Hormones are very powerful drugs. They have potentially serious/deadly effects. They should be taken under a doctor's supervision so that periodic blood tests can be run to avoid complications. If you are taking them under the supervision of a doctor, ask your prescribing physician. If you are not taking them under supervision of a doctor and by prescription be aware that the quality control may be poor and therefore the dosages may vary markedly. Under these conditions use extreme caution if you decide to take them, even by the usual route. You might ask the company that makes them for a product insert that describes the drug in detail and/or check a Physicians Desk Reference and Pharmacopia. Nurses study for years to learn the correct administration of medications and their effects. There is a reason for this. Use caution and good judgement.
August 29, 2008 12:03 AM BST
I take mine sublingually, hoping that some of the estradiol will enter the bloodstream directly and avoid the first pass of the liver. i wouldn't have thought it would be dangerous as a suppository, but I don't know for sure.
xx