August 15, 2010 11:51 PM BST
There are two types of anti-androgen, one blocks production, one blocks the receptors. I believe but might be corrected that the latter is now the preferred method.
As with most forms of drugs, after a period of time the body itself decides what it is going to do. So if and when it realises that testosterone is 'no longer required', it will begin to shut down production of it's own accord. This will also start to happen if comparatively large doses of oestrogen are introduced.
This is why medical supervision should always be in place, and unless one is thinking of taking things further, such as eventually to GRS, one should be very careful and have regualr tests to ensure nothing permanent occurs.
I was on oestrogen with a blocker, which definitely increased the effects, which pleased me greatly. However, after a couple of years, I could almost do without, for the reasons stated above.
So yes, continued use is likely to reduce the natural production of testosterone.
August 17, 2010 1:13 PM BST
From personal experience, I experienced a definite reduction in size of all 'parts', not just the testes, and have spoken to many others who confirmed they had as well.
There are obviously exceptions to most things, so there will be some who do not experience any changes at all, but my money would be on you will.
Bear in mind we are not talking weeks but on average about two years before there are noticeable effects.
If you are including oestrogen in the mix, the same sort of timescale applies to any changes in the breast area. Though once again, there are those who will claim they have breasts after a couple of doses - this is unusual and rare.