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    • June 19, 2017 6:41 PM BST
    • Trans friendly GP! they still are required to have a duty of care, that is any medication drugs prescribed are warranted,  a valid need, so you might be refered to a gender therapists before the GP makes any recomendations to an endo.   In this climate of litigation, GP's have to cover their backs.    Best of luck xxXxx

    • June 19, 2017 5:11 PM BST
    •   After 30 years fo kicking the tires i am finally on my raod to transition.... what a rough and rocky road to start onto.  I found an endo and when I tried to get referred they told me I had to go to a place called CAMH in Toronto Ontario.  That would be fine except they have an almost 2 year wait!!  I called them to see if I could get in any faster and was given some very helpful info.  So this Thursday I will be going to a trans friendly GP to start my journey and I am just wondering what to expect?  Am i going to be sat down and just talked to or will I maybe see blood work ordered? I have heard many say that i probably won't get any meds on the first visit but I don't want to wait any longer.  I have waited this long, Im almost 40 now so i think i know what i want.

    • June 4, 2017 2:42 AM BST
    • Hello I have a quick question has anyone hear heard of it making a significant difference injectioning into the thigh vs the glute region.  I have been on IM estradiol since January 2017 and the progress has been slow going.  For the majority of the time I have been injecting into my thigh area.  Here recently I decided to change to my hip area to see if that would make a difference.  What I believe was happening is my body is burning off the shot in the thigh too quickly and the levels drop precipitously before it has had a chance to do its magic. The last time I had some blood work done was back in early april in my estradiol was off the charts at 1800+pg/mL  I am going back to her in July to discuss this with her but I just wanted to get some differing idea and to see  if anyone else has gone through anyting similar.  

    • April 29, 2017 8:38 PM BST
    • Into my fourth week on estrogen. Breasts still get tender now and again but the munchies have at least departed. I'm noticing a few minor things that are pleasant. Slow but continuous breast development. Definite softening of my skin as well. The rate at which my hair is growing seems to have increased but that might be the gummies I got for hair/nails. The emotional changes are so incredible! Mental clarity like I've never had before. My already empathic feelings are even stronger than before. I feel a lot more for people that I used to. Things are making me laugh outloud rather than just to myself.

    • April 15, 2017 3:41 PM BST
    • Being on antiandrogens for over six months did a lot to clear my mind. The longer I was on them though the harder it became to present male at work because the sense of "wrongness" escalated the longer I was on them, especially once my endocrinologist increased them from the low dose I was on to something higher.


      Coming up on two weeks with E and a much higher dose of antiandrogens. It has been amazing so. Yes, just knowing that I started on estrogens has been huge for my mental state. Much of that is like a placebo effect for sure. It is like having an anti-anxiety medication in your purse to help with panic attacks and it reduces the anxiety and amount of panic attacks because you know that it is there.


      I am noticing physical changes as well as mental changes. Softer skin is definitely on of the changes. My hair seems softer and shinier too, growing faster, possibly. The munchies are much better, or I'm getting better and not giving into them. Continued breast development is definitely there. My bra pads are close to not being able to fit in my bra any longer.


      It is definitely a wonderful ride so far. Time to sit back and just enjoy the trip. :)

    • April 13, 2017 11:11 PM BST
    • To add to Crissy's comment, what was definitely not placebo was a very quick change in body scent and skin softening.  For me, things flipped at around two weeks to one month...everything else took a fair amount of time.  

      Traci xoxo

    • April 13, 2017 6:52 PM BST
    • In my experience and how other have described their initiation to HRT, the first few weeks are placebo effect, the comfort and knowledge to know one is finaly on the path to their desired destiny.

    • April 13, 2017 6:12 PM BST
    • Ultimately, you'll discover that the peace of mind and clarity you will develop will far outweigh any satisfaction you derive from the physical morphing!  Of course the perfect scenario is to have both! (smile)  But I truly most enjoy finally feeling just "right" after all of these years of not feeling "just right".  Hope that makes sense!

      Traci xoxo

    • April 13, 2017 11:04 AM BST
    • I've really enjoyed the past week being on estrogen. The munchies have calmed down, finally. I still get the tenderness frequently. Might just be imagination but I see improvements in development even after this short period of time. It might have something to do with the fact that I was almost 8 months on spiro before I started and my body was really "craving" hormones of some sort. Or, might just be my imagination.


      Still, I'm far more happy with them in my body and T much, much lower!

    • April 10, 2017 4:16 PM BST
    • 7+ years on HRT and the tenderness still manifests itself in indeterminant cycles!  It is welcomed because it usually means a growth spurt.  Mine had been very, very tender for the past 6-8 weeks...(smile)  

      The bottom line is you'll get what you get, no more and no less...just sit back and enjoy your journey!  It's all good...

      Traci xoxo

    • April 10, 2017 12:33 PM BST
    • Hi Cynthia, Just a comment .It takes a long while ,many months with blood levels being monitored to get an objective view of this,anyway you are right in the middle of it so it's going to be very subjective.Considering that the body has a lot of inertia to the effects of hormones,and also that certain body functions and parts are differently sensitive,and not forgetting there's the effect of T still about ,it's entirely Normal as Lucy says to get these sensations.Regarding the munchies, I used to be really bad but found that the long term effect of increasing Oestrogen[lowering muscle mass ]percentage] .Lowering T levels with suppressor decapapeptyl all under endocrinologists supervision was that I changed my diet and eat less and more healthily.Also in my case ,I became really intolerant to any alcohol.just can't handle it.I feel very healthy now,

    • April 10, 2017 11:03 AM BST
    • Thanks for the answer. I appreciate it. I have to comment one thing. Your signature is my favourit quote of all time, Polonius to his son in Hamlet. :)

    • April 10, 2017 9:11 AM BST
    • I don't remember getting the munchies, but do recall breast tenderness which comes and goes for the first couple of years.

      I'm sure they're both entirely normal.



    • April 10, 2017 2:21 AM BST
    • So, I've been taking estrogen for about a week now. I've noticed two things. First, I seem hungrier now. I want to munch on things all day long. From going to the gym and exercising I know about muscle pain after working out my my poor little boobs get the same sort of pain.


      Anybody else experience anything like this?

    • March 9, 2017 8:05 PM GMT
    • Hiya Justin. welcome to GS.

      Liz, realisation suddendly dawns,  I think when Justine said ''I am fully committed into becoming a trans'' I took it to mean that she  intends to fully transition, Trans means so many things, transexual a person who has transitioned and had whatever surgery etc, needed or just living a full time life,  transgender a person who is confused about their gender, perhaps not embarked on the physical changes or presentation.   You are right of course, one does not suddenly wake up and become transgendered.   They might suddenly wake up one day and decide they need to do whatever it takes to be happy in the gender they see themselves as.

    • March 9, 2017 1:02 AM GMT
    • Justin Timmons said:
      I am fully committed into becoming a trans and I'd like to start taking estrogen pills and/or progestin (only slightly understand the difference), but the problem is between all my bills I can't afford a prescription visit. Is it possible to use an OTC estrogen in order to start HRT? Or must it be a doctor appointed prescription?
      Hi Justin
      When Iread your post I did a kind of double take..."I am fully committed into becoming a trans " the immeadiate thought I had don't become trans you either are or you aren't. Depending on what flavour you are it may change how you may want to identify...So what kind of outcomes are you wanting from the HRT. Why don't you get a medical professional involved? OTC is certainly available and you can do it but without a great deal of knowledge you could end up really hurting yourself in all sorts of ways...

    • March 8, 2017 10:45 AM GMT
    • Hello Justin and welcome to the site.

      It is possible to buy OTC hormones, depending on which country you live in, though no-one would recommend it without medical supervision.

      If you feel you must "do it yourself" then it is hugely important to educate yourself. Not knowing the difference between progestin and etrogen is not a good starting point.

      But I don't mean to sound patronising...

      All you really need to start with is estrogen, which must be a very low dose to begin with (1 - 2mg for the first few months). The safest form is bio-identical estrogen (for example Estrace). Progestins, which are a synthetic version of progesterone should be avoided completely. Bio-identical (micronised) progesterone is safer but not entirely necessary for M2F feminisation.

      I'd advise anyone to spend considerable time reading up on the subject before embarking on hormone treatment. And if you're going to do it for any length of time then blood tests to monitor your health, liver function etc are essential.

      Good luck in your quest.


    • March 7, 2017 10:26 PM GMT
    • I am fully committed into becoming a trans and I'd like to start taking estrogen pills and/or progestin (only slightly understand the difference), but the problem is between all my bills I can't afford a prescription visit. Is it possible to use an OTC estrogen in order to start HRT? Or must it be a doctor appointed prescription?

    • January 31, 2017 11:34 PM GMT
    • So, my GP talked to the Endocrinologist that I saw. It turns out that if she feels I'm unready to start HRT she has to refer me to fill out this form that they Transition Readiness Evaluation, just to cross Ts and dot Is. He mentioned that because I was not able to relay the full story to her, she was distracted because her daughter was sick and brought her to work rather than cancelling my appointment, if I was able to explain the full story to her she might change her mind. Also, there are a few others that will fill out this form and I will search for them and see about getting it filled out sooner than the other person I'm already in contact with that is not available until the end of February.

    • January 15, 2017 11:55 AM GMT
    • They all start with the smallest doses I wouldn't self medicate. I could tell u proper dosages but I won't contribute to self medication. There's no doctor to monitor blood work. I'm st the highest dosages allowed by the medical professionals. And that is set according to my blood work. Wrong dosages could drop blood pressure to almost nill. In the danger zone. Skin gets extremely cold. I know these things. I been there. Be careful

    • January 13, 2017 2:35 PM GMT
    • All I will say is every female emotion you can't or can even imagine is possible on hrts. With out being born with the parts it goes into bypass. Like default. I can get all female feelings. All I wanna say.

    • January 13, 2017 2:31 PM GMT
    • Why are people so stuck in endos. Where I live they won't help our kind. I use a regular doctor that is well trained for this.

    • January 13, 2017 2:28 PM GMT
    • When u take time off from taking hormones the body goes Into menopause. Or could not a guarantee. Bet the web didn't share that to. I'm sick right now cause I didn't stay on top of my medication. I ran out and fell badly sick. I'm sure everyone differs. But that's me. Much the internet won't tell u.

    • January 13, 2017 2:24 PM GMT
    • Still there is so much the internet doesn't tell people I personally know this . I been on hormones a very long time. And transitioning well

    • January 13, 2017 2:10 PM GMT
    • That is a very good read and a wonderful article. Personally, I'd never consider self prescribing and buying hormones, online or street hormones. As the author mentions, I'd have no idea what to order or how much to take. Risking my life or doing self harm is not worth shaving a few months off of taking hormones.

    • January 13, 2017 1:36 PM GMT
    • The Internet is a wonderful resource and is a great source of information about trans issues. It is a lifeline for many enabling interaction with other trans people. The number of trans sites has increased enormously in the last two years and it provides the information required for people to attach terms of reference for the feelings they have. Some sites are better than others and many comment on the hormone interventions that are used to facilitate a physical transition. Depending on the site, the accuracy of this information varies from completely inappropriate to a very sensible overview. Armed with this information people proceed to buy their medication off the Internet from the numerous convenient but often expensive online pharmacies without any advice from a doctor.



      Doctor Richard Curtis.   I have been asked by a number of people to write about this issue from the medical perspective. I would hazard a guess that a third of my new patients have recently or currently self prescribed in this way for varying amounts of time. It is fair to say some people choose sensible regimes but others take wholly inappropriate drugs. Before the cynical reader assumes that I am writing this to encourage patients to come and see me, I can assure you that the reasoning which follows would be applicable to
      There are ten reasons why self-prescribing
      cross sex hormones obtained on the Internet is risky.
      any form of self-prescribing with any drug. It is advice I give my friends and advice I used to give as an NHS GP.

      There are ten reasons why self-prescribing cross sex hormones obtained on the Internet is risky.

      1. Firstly, the quality of the drugs obtained may be of a poor standard. There are some "rogue manufacturers" who do not comply with normal pharmaceutical manufacturing processes and are not regulated. "Drugs" with no active ingredient and pills with cement as a constituent are regularly discovered. There is no guarantee that the pill you think you are taking is what you ordered. Clearly such "drugs" will not have the desired effects and could clearly cause unusual or harmful side effects. These "manufacturers" make the packaging look convincing as this is not difficult to do.

      2. I commonly ask patients who have self-prescribed how much their drugs cost. Generally, they have paid much more for them than the high street chemists would charge with a private prescription. Testosterone injections and Oestrogen are actually quite cheap but patients are paying several times more than they need to. Hence the Internet is not necessarily a cost effective opt

      3. Prior to prescribing any drug, doctors undertake a risk assessment based on the individual patient's health to date, family history, age and the results from any test to determine the adequacy of kidney and liver function. Properly functioning liver and kidneys, which metabolise and excrete most drugs are essential. I undertake routine blood tests prior to prescribing. Whilst most patients are fit and healthy, the odd patient does have underlying problems, which they are unaware of. For instance, excess alcohol consumption can lead to abnormal liver function. This means that the body cannot adequately process drugs, particularly oestrogen, causing an inappropriate build up which may in turn lead to increased risk of adverse effects. Some patients do not realise that a family history of thrombosis, for instance, as well as having a personal history themselves, means that additional caution, counselling, baseline tests and monitoring, would be appropriate. The drugs used by doctors in every branch of medicine are tailored to the individual. So a "one cap fits all regime" is substandard practise.

      4. The exact drug used is important. Different drugs have different risk profiles and careful counselling of the patient and informed consent is a necessary prerequisite, particularly for the higher risk formulations. For example, the risk of thrombosis is much higher for Ethinylestradiol, which is found in contraceptive pills, than for 17 ß-Oestradiol, which is why the former has fallen from favour. There are patients who put themselves onto this drug who should not be on it and put themselves at significant risk of serious side effects. There are transmen who take things like growth hormone or high doses of body building steroids in addition to the usual Testosterone injections without understanding the implications of this.

      5. Few patients are aware of the mechanisms of absorption, distribution, metabolism and elimination of drugs. An at risk individual may not appreciate the way different delivery methods impact the tolerability and drug load the body has to deal with. For instance, the shorter acting Testosterone formulations have quick cycling peaks and troughs every two weeks. A high peak over the normal range for Testosterone is much more likely to lead to complications than the longer acting slower onset injections such as Nebido. Similarly, the troughs are often troublesome and a more balanced daily administration utilising the transdermal delivery method may well be more appropriate for some individuals. Such discussions are an essential part of the doctor's role in helping patients to achieve their physical transition in the safest and most stress free way.

      6. The actual dosage chosen by patients varies markedly. Some take very tiny doses and really may as well not bother. Others overdo it without due concern. One of the basic tenets of prescribing is to use the lowest dose to achieve the desired effect. Every individual varies in their ability to absorb drugs, particularly orally, as well as the ability of these drugs to work in a beneficial way. Again the "one dose fits all" impression given by the Internet is misleading. The Internet doesn't generally mention the long list of drugs which can increase or decrease the absorption of oestrogen for instance. Doctors are used to keeping these things in mind and advise accordingly.

      7. Patients very under appreciate the impact of what is called co-morbidity. Co-morbidity is the impact that other health problems may have on the risks associated with taking cross gender hormones. Compromised liver and kidney function has already been mentioned. In transmen, this may be something called haemochromatosis, a relatively common inherited condition which predisposes the person to make too many read blood cells. If this is significant, it can increase the clotting tendency of the blood, causing a thrombosis in the form of a pulmonary embolus or deep venous thrombosis in the leg. Testosterone also has this effect and means dosage frequency or formulation (the method of delivery of the drug e.g. injection, gel or patch) adjustment may be necessary from the outset. Those with diabetes, high blood pressure, a history of strokes, heart disease or clotting tendency can all be made worse by the administration of Oestrogen. Failure to appreciate this and look out for the early relevant symptoms can jeopardise subsequent treatment.

      8. All long-term drugs should be monitored closely. Any patient on repeat prescriptions will tell you that they have to see their GP once a year to review their medication. Things change; the body is a constantly evolving organism. From one year to the next, it is not the same. Over many years in Practise, my experience is that patients do not understand this. It is often said, "but it has been fine up until now". The effect of aging is the most obvious example. Over forty, the body is starting to show significant changes. It is slowing down and does not tolerate drugs as well as a twenty year old. Fifty plus, sixty plus, seventy plus all show step changes in the factors to take into consideration in re-prescribing. Remember, it is not always possible to know what is lurking within us. Cancers can take ten years to become evident. Arterial disease causing heart attacks and strokes is not obvious until you actually have a significant heart attack or stroke. The risks of these types of things are known better by medical practitioners and a change in medication is often prudent to mitigate against these risks. I suspect patients think of monitoring in terms of blood tests and admittedly, these are a part of it. Recent research suggests that it may not be necessary to measure anything other than full blood count and Testosterone levels, with LH / FSH if post hysterectomy may be all that is needed in transmen. In post-operative transwomen not on Ethinylestradiol, liver function tests are somewhat redundant but Lipids and Glucose are probably not. An annual Oestradiol plus LH / FSH to monitor adequate replacement as requirements change over time is probably useful to inform decision making. But for both groups, an annual blood pressure reading is hugely important. Oestrogen is well known to increase blood pressure. We have not studied sufficient numbers of transmen for long enough to know what the actual long term risks are but high blood pressure may be the first marker of increased cardiovascular risk. Genetic men have a higher incidence of coronary heart disease and it is not known whether this transfers to transmen taking testosterone. A prudent change to the dosage and method of administration plus adequate management of other conditions and drugs is all that is proposed. It is not say that withdrawal treatment is necessary but one wants to be an alive trans patient - not an avoidably dead or ill one.

      9. It follows from the above that adequate supervision of hormone administration will facilitate early or appropriate management of unrelated illness or untoward effects of any drug. Untoward effects do occur, including thrombosis as a DVT or PE, polycythaemia and breast cancer. Cancers generally happen and increase thrombotic risk; high blood pressure happens.

      10. Finally, common sense dictates that self-prescribing potent drugs with a multitude of surrounding issues which are poorly understood is a dangerous idea. Consult those who are expertly aware of all the above. I am a great fan of DIY but still realise a professional tradesman has far more skills and experience than I and on average, is going to do a better job. It is not a perfect world and even doctors don't always get it right. Patients are even less likely to.

      There are reasons why people decide to self medicate. But I believe however, it is false economy financially, physically and emotionally in bearing the burden of prescribing. I have not gone into every possible scenario but can certainly say that it would be extremely likely if all data was analysed, everyone who self prescribes would have some issue pertaining to one of the above points. Don't do it!



    • January 13, 2017 1:40 AM GMT
    • My family doctor had ordered some blood work before hand but had ommitted a few tests that she likes to have; prolactin, testosterone, and a few others but I can't remember the names. :P From what she saw there was nothing that raised any concerns such as high cholesterol, diabetes, etc. Her feeling was that I need a better plan in place before starting HRT and I'm good with that. What helps is that I don't have to get another referal to her. I can just call and make the appointment next time.

    • January 13, 2017 12:28 AM GMT
    • Idealy you should have blood tests done, the endo will base the levels of your HRT on things like testesterone levels,   People found to have conditions like AIS, would have a different prescription.   Also other conditions would impact on your health if you were precribed HRT.

    • January 13, 2017 12:24 AM GMT

    • January 12, 2017 10:54 PM GMT
    • Her suggestion was not about analyzing anything. It was about making informed choices. The doctor and I chatted a bit, it wasn't a 30 second, "No, you need to do x y z first." No, we talked about my plans, if I was "out", etc. and she asked me if I was comfortable with her plan, and I am. I could have started hormones 4 months ago if I really pushed things. Whether I start hormones tomorrow, 2 weeks or 4 months is not important. What's important is that I'm happy with the direction I'm going and I'm totally happy with it.

    • January 12, 2017 10:49 PM GMT
    • Same old answers, any consultant, doctor or surgeon has a duty of  care, which includes establishing a need, it would be incompetant to just hand out prescriptions, perform surgery on demand, especially in this age of litigation.   It is understandable that they hesitate,

      Some people don't do research, even know what a regime of HRT can do to their endocrine system, how it will effect them, or any adverse side effects that could happen.  be content that when a doctor/specialist does prescribe drugs, they are confident they are making the right decision for you.   Firstly an endo must review your current health do whatever tests are needed, then a second appointment after the tests have been done in a lab to explain what you will be taking and explain what you should do and not do and explain the what if's.   A good example you cannot legally drive a car without first proving your capable of driving one, taking a test and getting a certificate to prove it,   Too many want it now, regret it later.

    • January 12, 2017 10:32 PM GMT
    • That Much hassle to get on this medication is unwarranted. What I told u is everything u need to know. Do many things aren't in the internet. Why two times. What's to analyze? You are or your not. This is permanent. There's no going back. People can be so ridiculous. And it's people that do not know ****. Unless they are transgender.

    • January 12, 2017 10:02 PM GMT
    • So, I did have my appointment with the endocrinologist today. She was very nice and very understanding, I will really like working with her. She gave me sume reading material and a few contacts for services in the area. She was not comfortable starting female hormones today. Instead she has asked me to speak with a psychologist in the area that helps people with the gender identity issues, at least twice, and then we will look at starting HRT. I'm totally cool with this idea as I have only talked plans with my family doctor and I don't have a plan for transitioning/coming out other than I want to. So, waiting a few more months definitely will not hurt at this point and at least the spironolactone is having enough of an effect to help with some of the angst that is is causing.

    • January 8, 2017 7:08 AM GMT
    • That's really strict compared to America. There is no gate keeping where I am.

    • January 7, 2017 11:31 PM GMT
    • Thanks for the reply in regards to insurance. I'm just concerned about my job because it is so important to me right now. It is not just the money either, right now the structure that it is providing day to day will be rather important. Not being able to present fully the way I'd like is hard but I'm finding little things that I can do that help in that regard.


      In Ontario, the province I live in, things have really turned around for people with gender identity issues. At one point you first had to be diagnosed by a specialist at a gender clinic with incredibly long wait times just to get an appointment. Then there was a battery of humiliating tests that you had to go through. You then need to live outwardly as your chosen gender for 1 to 2 years before any HRT. You'd then be another few years after that before they'd consider assessing if you were eligable for gender reassignment surugery, if that is what you wanted.


      The regulations are no where near as rigid now that it is Gender Dysphoria rather than Gender Identity Disorder in the new DSM-5. You no longer have to go to the gender clinic and convince a doctor there hat you were born the wrong gender. Almost any doctor can refer you to another doctor that monitors the HRT and that's it. The doctor I will be seeing is just an endocrinologist that deals with body chemistry. If your regular physician is comfortable enough they can prescribe the treatment themselves.


      Actually, we are a lot luckier here than in most places here in regards to gender dysphoria. Our provincial health care will now pay for gender reassignment surgery, though the waiting list is long if you go that route. There is even a new ruling that they will pay for breast augmentation if you can prove you've been on HRT for an extended period of time with no substantial increase in breast development.

    • January 7, 2017 9:57 PM GMT
    • Hiya Cynthia,

      I should imagine that whatever your prescribed and the nature of your consultations would come under the doctor patient confidentiality clause, which would cover any subsequent prognosis/prescriptions/medications invoiced to the adminstrators of your health plan, generally the onus is upon the patient to inform any other insurance cover firms of any diagnosis, medications that could prevent you from cover, for example, driving insurance if the condition or medication impacted on your ability to drive safely.

      Assuming you have a clinical diagnosis of a gender identity problem by a specialist, here in the UK once one has been diagnosed and refered to a gender clinic, our national health system regulations and the UK Gender Recognition Act requires that prescripyions/medication and ongoing treatments should be made available.

      I am not sure what the health service regulations are in respect of Canada.

    • January 7, 2017 8:43 PM GMT
    • Well, the title sums it up. First, I'm still very stuck in the closet because I haven't come out at work yet and I need the job, at least for the short term. Second, I started testosterone blockers back in August/September. I like what they have done and continue to do for me. On Thursday I've got an appointment with the endrocrinolgist that works  with people who want to under go HRT. I'm very excited to do so but at the same time nervous about the appointment. I don't know as much as I'd like to about what options there are today. As well, I do have a health plan at work but if I have them pay for the blockers and hormones do they get a report of what medications I'm prescribed that they pay for? If they did then I'd either pay for anything myself or wait until I'm more ready to come out at work.


      Anybody have experience with health insurance, prescriptions and reports in Canada?

    • December 10, 2016 8:59 PM GMT
    • I take Vit D3, it's aptly named the sunshine vitamin, where one does'nt get enough sun, check your folic acid as well, Baby raw spinach, watercress and Avocados are a great natural supplement as well. Also don't forget your five a day Apple pie, a chocolate orange, a bottle of fermented grapes, Banana fritters and Strawberry ice cream .

    • December 10, 2016 7:39 PM GMT
    • has anyone tried vitamin d3.It seems to be very important in controling vitimans and minerals in hour body and helps the immune system and supports bone health.  I take my hormones in the morning and vitamin d3 at night. the weird thing is after I take it,about one hour later I get breast tenderness.I did some research and found others have had this happen too.further research also comes up as vitamin d3 is not a vitamin but a hormone. Has anyone here tried this and had the same breast tenderness.

    • November 27, 2016 6:08 AM GMT
    • How effective are estradermal patches for feminization?

    • November 3, 2016 2:48 AM GMT
    • Just FYI for those who plan on ordering from Online Pharmacies without a prescription.. I was nervous but took the plunge and ordered from two different sites last month successfully paying with bitcoin (which wasn't that hard to set up)  - Progynova, came in a little over two weeks with good expiration date (2020) - oestrogel came in about three weeks also with good expiration date (2019)

      Both sites gave discounts for bitcoin (i believe 10% for inhouse and 25% for Pharmaoffshore), but the packaging for pharmaoffshore was out of box with the boxes in the package flat separate from the tubes to save space, oh and pharmaoffshore shipped out of Thailand

    • October 18, 2016 6:34 AM BST
    • I have been taking female contaceptive pills since 9 months though irregularly.My breasts have developed and hips have widened .even my testis size has decreased .I want to know that at what stage the effects would become permanant or irreversible.

    • August 27, 2016 9:54 AM BST
    • I do not see it here in a search, so I'll add it here.

      I am looking for more information from people's experiences on using a menstrual cycle for periodically adjusting the estrogen level in a cyclical manner.  I find that using a standard X mg of estradiol is not really working for me (I have been on hormones for 18 years and went full-time legally 17 years ago), in that I see evidence of estrogen insensitivity after so many years of using the same dosage.  I am mostly through my first cycle (where the secondary peak comes after the interim bottom before bottoming out at the end of the cycle), and I see major results already.  Not only the enlarged breast development, but just how I feel and think.

      Maybe it's not evident yet, but I've already hit the very high peak of the cycle and bottomed out at the interim for a day, and I don't seem to feel a difference towards the negative side, like being moody or crying.  I noticed that on a lower, stable dosage, being post-orchie for 10 years, I felt like the masculine side was coming out, like the tendency to read about a certain group of people, its history of conquest, the dangers evident, and what their strategies are for world domination, talking to people about having to arm themselves against this group of people.  I thought about doing this, doing that.  I also noticed that I was losing breast mass and staying there.  I noticed that when I started the menstrual cycling, these male feelings or tendencies started to abate and I felt the tell-tale signs of breast development, sensitive nipples, which I hadn't felt in years.  Sure enough, the development started a few days later.

      I've thought about the cycling of estrogen...  In recent weeks, I've begun to understand what could be happening as one goes through the menstrual cycle.  It seems to be that the effect of such a cycle intended for the "cycling" of the uterus lining and the ovulation is that when estrogen levels are low, the body maintains its shape or female fat levels in the body; when it ramps up for a few days towards the peak, the feminization effect steps up and is reached for that cycle; and then the estrogen level drops back down fairly hard before gradually increasing up to less than half the peak level for a few days before returning towards the "base line" level near the end of the cycle.  That hard drop down seems to give the estrogen receptors a quick break before the level goes back up partially for a second time.  I would think that because the receptors are "freshly exposed" from the high peak of a few days before, they are able to respond "anaphylactically" to that second smaller peak before estrogen levels down to the base level for the next 7-10 days for the next cycle, meaning a higher response to a smaller level of estrogen than the peak level.  I assume that in a woman's body, the amount of feminization "lost" during the "base line" period would be less than what was gained in the previous cycle, assuming no pregnancy happens.  So the amount of feminization increases to its maximum potential for the body through periodic resting and restoration of maximum response to estrogen and layering the results one on top of the other.  Your body this cycle is slightly more feminized than it was last cycle (though it takes several cycles for something to become noticeable) until you reach your max potential.

      I realized that a reason that drug addicts go for higher dosages is because of insensitivity to the drugs if taken continuously over a period of time, and noticing that if I was on a steady diet of alcohol (2-3 beers per week) and stopping, then noticing sensitivity after picking up again a few months later, and then noticing the effect dropping after a month (I don't drink anymore because I don't want health issues with it).  It seems very interesting that the female body was designed with this mode of functioning so that it does two things at once - periodically shed the uterus lining in response to no egg fertilization and the periodic egg release, and to build up the secondary sexual characteristics over time, rapidly through estrogen cycling to maintain estrogen recepter sensitivity.

    • August 15, 2016 8:03 PM BST
    • Thanks so much for all your advice, I've been struggling to find a place like this to ask advice for some time. Nice to know there still genuine people in the world that want to help others.
      Truth be told I can't fully transition for a good few years yet. But I feel so much better and happier with some curves these days. I've always wanted a female body since a very young age. But that's not the way life pans out. Am much happier since deciding to try and develop breasts. They may be wee diddies but they are mine and I love them.
      Will take on board all you good advice and thanks for being a true star! Xx

    • August 15, 2016 6:26 PM BST
    • It's best to start on a minimal dose, 1 or 2mg per day.

      Stop taking the herbs because they can interfere with oestrogen receptors and not let the real stuff through.

      Changes may be irreversible. I wouldn't really recommend anyone take hormones if they didn't plan to fully transition.


    • August 15, 2016 6:10 PM BST
    • Thanks much appreciated advice, yes am married to a very understanding partner. I've managed fine on the herbs so far without any loss of sexual function. So I will monitor that carefully. What would be a good starting dose for Estradiol?
      I Will defenitly get some bloods done regularly as well.

    • August 15, 2016 6:04 PM BST
    • Probably not, as estradiol will quickly and usually quite drastically lower testosterone levels.

      I'd also highly recommend anyone not to take anti-androgens without medical supervision. Even on estradiol, the odd blood test to monitor liver function etc wouldn't hurt.

      Your profile says you're married, I'm sure it's none of my business but are you both going to be happy when you start losing sexual function? Female hormones tend to do that...


    • August 15, 2016 3:09 PM BST
    • Would I still need to use anti- androgens if I was taking Estradiol? X

    • August 15, 2016 3:03 PM BST
    • Thank you much appreciated x

    • August 15, 2016 12:09 AM BST
    • Estradiol is the best hormone. There aren't really different types that do different things; estradiol alone will give feminisation in all areas.

      The safest way is to see a doctor.